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Current Clinical Trials

North York General Hospital in Toronto is expanding its clinical trials infrastructure to support increased participation and provide additional treatment options to our patients.

Alzheimer's disease
A Multi-centre, Double-blind, Parallel-group, Randomised Controlled Study to Investigate Efficacy and Safety of Orally Administered BI 425809 During a 12-week Treatment Period Compared to Placebo in Patients With Cognitive Impairment Due to Alzheimer's Disease
Link to clinicaltrials.gov for more information.

Bacteremia
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness- BALANCE on the Wards: A Pilot RCT
Link to clinicaltrials.gov for more information.

Bacteremia
Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: Randomized Controlled Trial
Link to clinicaltrials.gov  for more information.

Breast cancer
Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy
Link to clinicaltrials.gov for more information.

Breast Cancer
A Randomized, Open-Label, Phase 3 Study of Abemaciclib Combined With Standard Adjuvant Endocrine Therapy Versus Standard Adjuvant Endocrine Therapy Alone in Patients With High Risk, Node Positive, Early Stage, Hormone Receptor Positive, Human Epidermal Receptor 2 Negative, Breast Cancer
Link to clinicaltrials.gov for more information.

Breast cancer
Treat ER+ight:Treatment of Canadian Postmenopausal Women with ER+ Advanced Breast Cancer in the Real-World Setting with Hormone Therapy ± Targeted Therapy
Link to clinicaltrials.gov for more information.

Bronchiolitis
Oxygen Saturation Monitoring in Bronchiolitis
Link to clinicaltrials.gov for more information.

Colon Cancer
A Phase III, Randomised, International Trial Comparing mFOLFIRINOX Triplet Chemotherapy to mFOLFOX for High-risk Stage III Colon Cancer in Adjuvant Setting
Link to clinicaltrials.gov for more information.

Colorectal cancer
Extended Peri-operative Tinzaparin to Improve Disease-free Survival in Patients With Resectable Colorectal Cancer (PERIOP-01)
Link to clinicaltrials.gov for more information.

Kidney cancer
A Phase III, Multicenter, Randomized, Placebo-Controlled, Double-Blind Study of Atezolizumab (Anti−PD-L1 Antibody) as Adjuvant Therapy in Patients With Renal Cell Carcinoma at High Risk of Developing Metastasis Following Nephrectomy.
Link to clinicaltrials.gov for more information.

Liver disease
 
  • Nonalcoholic Steatohepatitis
    A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic Steatohepatitis.
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic Steatohepatitis
    A Phase 2 Double-blind, Randomized, Placebo-controlled, Dose-finding Study to Evaluate the Safety, Tolerability and Efficacy of Volixibat Potassium, an Apical Sodium-Dependent Bile Acid Transporter Inhibitor (ASBTi) in Adults with Nonalcoholic Steatohepatitis (NASH)
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic Steatohepatitis
    STELLARIS: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Cenicriviroc for the Treatment of Liver Fibrosis in Adult Subjects with Nonalcoholic Steatohepatitis.
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic Steatohepatitis
    A Phase 2 Dose Ranging, Randomized, Double Blind, and Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects with Non-Alcoholic Steatohepatitis (NASH).
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic Steatohepatitis
    Investigation of efficacy and safety of three dose levels of subcutaneous semaglutide once daily versus placebo in subjects with non-alcoholic steatohepatitis.
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic Steatohepatitis
    A multi-centre, double-blind, parallel-group, randomised, placebo controlled phase II a study to investigate safety, tolerability, pharmacodynamics, and pharmacokinetics of different doses of orally administered BI 1467335 during a 12-week treatment period compared to placebo in patients with clinical evidence of NASH.
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic fatty liver disease
    A phase 2a, randomized, double-blind, placebo-controlled, dose-ranging, parallel group study to evaluate safety, tolerability, and pharmacodynamics of pf-05221304 administered daily for 16-weeks to adult subjects with nonalcoholic fatty liver disease.
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic fatty liver disease
    A Multicenter Non-Alcoholic Fatty Liver Disease Biospecimen Collection.

  • Chronic Hepatitis B
    A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Switching from Tenofovir Disoproxil Fumarate (TDF) 300 mg QD to Tenofovir Alafenamide (TAF) 25mg QD in Subjects with Chronic Hepatitis B who are Virologically Suppressed.
    Link to clinicaltrials.gov for more information.

  • Chronic Hepatitis B
    A Phase 2, Open-label Study to Evaluate the Safety and Efficacy of Switching to Tenofovir Alafenamide (TAF) from Tenofovir Disoproxil Fumarate (TDF) and/or Other Oral Antiviral Treatment (OAV) in Virologically Suppressed Chronic Hepatitis B Subjects with Renal and/or Hepatic Impairment.
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic Steatohepatitis
    A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Obeticholic Acid in Subjects with Compensated Cirrhosis due to Nonalcoholic Steatohepatitis.
    Link to clinicaltrials.gov for more information.

  • Nonalcoholic Steatohepatitis
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Selonsertib, GS-0976, GS-9674, and Combinations in Subjects with Bridging (F3) Fibrosis or Compensated Cirrhosis (F4) due to Nonalcoholic Steatohepatitis (NASH).
    Link to clinicaltrials.gov for more information.


Postoperative ileus
Does Bowel Stimulation Before Loop Ileostomy Closure Reduce Postoperative Ileus? A Multicenter Randomized Controlled Trial
Link to clinicaltrials.gov for more information.