Current Clinical Trials

North York General Hospital in Toronto is expanding its clinical trials infrastructure to support increased participation and provide additional treatment options to our patients.

Bacteria

Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness: Randomized Controlled Trial 
Link to clinicaltrials.gov  for more information.

Breast cancer

Comparison of Axillary Lymph Node Dissection With Axillary Radiation for Patients With Node-Positive Breast Cancer Treated With Chemotherapy 
Link to clinicaltrials.gov for more information.

Treat ER+ight:Treatment of Canadian Postmenopausal Women with ER+ Advanced Breast Cancer in the Real-World Setting with Hormone Therapy ± Targeted Therapy 
Link to clinicaltrials.gov for more information. 

A Phase III Double-blind Randomised Study Assessing the Efficacy and Safety of Capivasertib/+Paclitaxel vs Placebo+Paclitaxel as First-line Treatment for Patients With Locally Advanced (Inoperable) or Metastatic TNBC.
Link to clinicaltrials.gov.

Colon Cancer

A Phase III, Randomised, International Trial Comparing mFOLFIRINOX Triplet Chemotherapy to mFOLFOX for High-risk Stage III Colon Cancer in Adjuvant Setting
Link to clinicaltrials.gov for more information.

Colorectal cancer

Extended Peri-operative Tinzaparin to Improve Disease-free Survival in Patients With Resectable Colorectal Cancer (PERIOP-01) 
Link to clinicaltrials.gov for more information.

Lung Cancer

A Phase II, Single Arm Study Assessing Efficacy of Osimertinib With Savolitinib in Patients With EGFRm+ MET+, Locally Advanced or Metastatic Non Small Cell Lung Cancer Who Have Progressed Following Osimertinib Treatment (SAVANNAH Study)

Link to clinicaltrials.gov for more information.

Critical Care

Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The PROMIZING Study
Link to clinicaltrials.gov for more information.

Liver disease 

  • Nonalcoholic Steatohepatitis
    A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of Obeticholic Acid in Subjects with Nonalcoholic Steatohepatitis.
    Link to 
    clinicaltrials.gov for more information.
  • Nonalcoholic Steatohepatitis
    STELLARIS: A Phase 3, Multicenter, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Cenicriviroc for the Treatment of Liver Fibrosis in Adult Subjects with Nonalcoholic Steatohepatitis. 
    Link to 
    clinicaltrials.gov for more information. 
  • Nonalcoholic Steatohepatitis
    A Phase 2 Dose Ranging, Randomized, Double Blind, and Placebo-Controlled Study Evaluating the Safety, Tolerability, Pharmacokinetics and Efficacy of EDP-305 in Subjects with Non-Alcoholic Steatohepatitis (NASH).
    Link to 
    clinicaltrials.gov for more information.
  • Nonalcoholic fatty liver disease
    A Multicenter Non-Alcoholic Fatty Liver Disease Biospecimen Collection.
  • Chronic Hepatitis B
    A Phase 3, Randomized, Double-Blind Study to Evaluate the Efficacy and Safety of Switching from Tenofovir Disoproxil Fumarate (TDF) 300 mg QD to Tenofovir Alafenamide (TAF) 25mg QD in Subjects with Chronic Hepatitis B who are Virologically Suppressed. 
    Link to 
    clinicaltrials.gov for more information.
  • Nonalcoholic Steatohepatitis
    A Phase 3, Double-Blind, Randomized, Placebo-Controlled, Multicenter Study to Evaluate the Efficacy and Safety of Obeticholic Acid in Subjects with Compensated Cirrhosis due to Nonalcoholic Steatohepatitis.
    Link to 
    clinicaltrials.gov for more information.
  • Nonalcoholic Steatohepatitis
    A Phase 2, Randomized, Double-Blind, Placebo-Controlled Study Evaluating the Safety and Efficacy of Selonsertib, GS-0976, GS-9674, and Combinations in Subjects with Bridging (F3) Fibrosis or Compensated Cirrhosis (F4) due to Nonalcoholic Steatohepatitis (NASH).
    Link to 
    clinicaltrials.gov for more information.
  • Nonalcoholic Steatohepatitis (NASH) and Liver Fibrosis
    A Randomized, Double-blind, Multicenter Study to Assess the Safety, Tolerability, and Efficacy of a Combination Treatment of Tropifexor (LJN452) and Cenicriviroc (CVC) in Adult Patients With Nonalcoholic Steatohepatitis (NASH) and Liver Fibrosis. Link to clinicaltrials.gov for more information.
  • Nonalcoholic Steatohepatitis (NASH) and Liver Fibrosis
    A Multicenter, Randomized, Double-Blind, Placebo-Controlled Phase III Study to Evaluate the Efficacy and Safety of Elafibranor in Patients With Nonalcoholic Steatohepatitis (NASH) and Fibrosis.
    Link to clinicaltrials.gov for more information.

Postoperative ilieus

Does Bowel Stimulation Before Loop Ileostomy Closure Reduce Postoperative Ileus? A Multicenter Randomized Controlled Trial 
Link to clinicaltrials.gov for more information.